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Symbol
Name
ID

Spi1
Spi-1 proto-oncogene
MGI:98282

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Decreased circulating IgA level	Decreased circulating IgG level	Decreased circulating total IgM	Agammaglobulinemia	Transient neutropenia	Absent circulating B cells	Recurrent sinusitis	Recurrent respiratory infections	Meningitis
Disease(s) Associated with SPI1
agammaglobulinemia 10

Mouse Phenotypes

abnormal granulocyte differentiation

abnormal neutrophil differentiation

abnormal macrophage differentiation

small thymus

decreased thymocyte number

enlarged spleen

increased spleen weight

spleen hyperplasia

abnormal leukopoiesis

abnormal B cell differentiation

decreased pro-B cell number

arrested B cell differentiation

abnormal T cell differentiation

abnormal double-negative T cell morphology

decreased double-negative T cell number

increased double-negative T cell number

decreased double-positive T cell number

abnormal myelopoiesis

failure of myelopoiesis

impaired myelopoiesis

abnormal granulocyte morphology

decreased neutrophil cell number

increased neutrophil cell number

decreased granulocyte number

increased granulocyte number

abnormal B cell number

decreased mature B cell number

absent mature B cells

decreased B-1a cell number

increased B-1 B cell number

increased B-1b cell number

decreased B cell number

absent B cells

decreased pre-B cell number

abnormal T cell subpopulation ratio

abnormal T cell number

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

decreased T cell number

increased T cell number

increased lymphocyte cell number

decreased macrophage cell number

abnormal microglial cell morphology

abnormal monocyte morphology

abnormal spleen morphology

decreased spleen red pulp amount

increased IgM level

sepsis

Availability

Mouse Genotype

Spi1^tm1.1Dgt/Spi1^tm1.1Dgt

Spi1^tm1.3Dgt/Spi1^tm1.3Dgt

Spi1^tm1Kast/Spi1^tm1Kast

Spi1^tm1Ram/Spi1^tm1Ram

Spi1^tm1Rpd/Spi1^tm1Rpd

Spi1^tm1Sing/Spi1^tm1Sing

Spi1^tm3Dgt/Spi1^tm3Dgt

Spi1^tm1.2Nutt/Spi1^tm1.2Nutt
Tg(Mx1-cre)1Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23